It is December 1967, and with Christmas fast approaching, life in Poplar is returning to normal after the terrible train crash.
The midwives move the maternity clinic into new premises and are delighted when one of their first patients through the door is Rhoda Mullocks, who the team know well. Rhoda is heavily pregnant and understandably nervous after her last baby was born with limbs affected by Thalidomide.
Nurse Crane cares for a heavily pregnant single mother, recently released from prison, while Sister Frances is called out to deliver a Sylheti mother's child in a garment factory in a rough area of Poplar.
Meanwhile, Fred decides that Poplar needs to come together to raise money for those families still affected by the train crash and pitches the wonderful idea of a festive talent show – Poplartunity Knocks!