Billionaire entrepreneur Edward Vogler spends $100 million on Princeton-Plainsboro Teaching Hospital and becomes the new Chairman of the Board. As a businessman, Vogler intends to turn the clinic into a profitable venue for his new biotech venture and plans to eliminate the financially draining services of Dr. House. Meanwhile, a businesswoman who has it all - perfect life, perfect body, perfect job - is inexplicably paralyzed. When he diagnoses her secret, House must risk his career and medical license to get her a necessary transplant.