Chuck battles with his cover love life and real love life when he meets a very pretty girl named Lou, who seems interested in the real Chuck. On the other hand, his relationship with Sarah heats up as they go on a double date with Ellie and Captain Awesome and try to explain their sex life. Meanwhile, a poison specialist is trying to obtain codes to nuclear facilities and is using a "truth" poison to help get his answers. After all are exposed to the truth, Chuck soon discovers a lot about his partners.