Anthony Bourdain takes a personal journey through this formerly bohemian New York City neighborhood, as he meets, shares meals and reflects with music, film and art trailblazers including Richard Hell, Deborah Harry and Chris Stein, Lydia Lunch, Fab 5 Freddy, Danny Fields, Amos Poe, Jim Jarmusch, Kembla Pfahler, John Lurie, Clayton Patterson, Hugh Mackie, Joe Coleman, Alex Harsley, Jim Power, and Harley Flanagan, whose collective cultural impact in the 1970's and '80's has sustained through the decades.